Impact of 50% ethanolic extract of Calendula officinalis (flower) on the reproductive function of male albino rats (Rattus norvegicus)

Oral administration to male rats of 200mg kg-1 body weight of an extract of Calendula officinalis flowers every day for 60 days did not cause loss of body weight, but decreased significantly the weight of the testis, epididymis, seminal vesicle and ventral prostate. Sperm motility as well as sperm density were reduced significantly, resulting in 80% loss of fertility. Serum testosterone levels showed highly significant reduction. Total protein and sialic acid in the testis, epididymis, seminal vesicles and ventral prostate decreased significantly, and testicular cholesterol was elevated. All measured haematological parameters were unchanged.