Resistance patterns of Pseudomonas aeruginosa isolated from HIV and Non-HIV patients with lower respiratory tract infections

ABSTRACT: The increase in occurrence of infections due to opportunistic gram-negative bacilli in patients with impaired host defences emphasizes the need for information on the antibiotic susceptibility of the organisms that infects such patients. Pseudomonas aeruginosa are becoming increasingly resistant to antimicrobial agents, and serious infections caused by these organisms often require immediate attention as they cause treatment failures. In vitro antimicrobial susceptibility data are required for successful therapy because acquired resistance to such antimicrobials as β-lactams, fluoroquinolones and aminoglycosides is so prevalent in P. aeruginosa. The study was carried out in Chennai during the period May 2007 and March 2009. 69 isolates of Pseudomonas were isolated from HIV and 24 isolates were isolated from Non-HIV populations with lower respiratory tract infections. The antibiotic susceptibility pattern of all the isolates was studied for 12 antibiotics to find the multi drug resistant (MDR) isolates for which the minimum inhibitory concentration (MIC) were studied according to CLSI (2009). KEYWORDS: Antibiotic resistance; P. Aeruginosa; MDR; HIV; Lower respiratory tract infection; MIC Internet Journal of Medical Update 2012 January;7(1):8-12