Hepatoprotective action of Pterocarpus marsupium against streptozotocin-induced oxidative stress

Pterocarpus marsupium Roxb. (Leguminosae) is widely used in Ayurvedic medicine as Rasayana. for management of various metabolic disorders including hepatotoxicity. Treatment of diabetic rats with methanol extracts of P. marsupium at 100 and 300 mg per kg-bwt per day for 21 days dose-dependently decreased serum glucose level. The higher dose exerted a protective effect on antagonized biochemical parameters such as reduced glutathione, superoxide dismutase and lipid peroxidation, and altered towards the normal levels hepatic mass, protein and glycogen content. In conclusion present results suggest antidiabetic, hepatoprotective as well as antioxidant effect of P. marsupium.