Mechanisms of the training response in patients with peripheral arterial disease – a review

Exercise training has proved to be a beneficial treatment for patients with peripheral arterial disease (PAD) suffering from the symptom of intermittent claudication. The mechanism by which symptomatic improvement occurs is unclear. The review summarises the mechanism of the training response in patients with PAD, focusing on improvements in bloodflow as well as biochemical, muscle recruitment and psychological adaptations. Possible areas of future research are suggested.