A Commentary on “TGF-β1-Induced Expression of the Anti-Apoptotic PAI-1 Protein Requires EGFR Signaling”

Plasminogen activator inhibitor-1 (PAI-1) has been found to affect a number of important cell processes and therefore abnormal expression of PAI-1 has been associated with a number of diseases and disorders. Understanding the transactivation of PAI-1 may result in identifying novel therapeutic targets.