3′ untranslated region 1630 C>T polymorphism of prohibitin increases risk of breast cancer

ntranslated region 1630 C>T polymorphism of prohibitin increases risk of breast cancer Original Research (250) Total Article Views Authors: Tang L, Zhao Y, Nie W, Wang Z, Guan X Published Date March 2013 Volume 2013:6 Pages 177 - 182 DOI: http://dx.doi.org/10.2147/OTT.S40997 Received: 11 December 2012 Accepted: 11 January 2013 Published: 11 March 2013 Lin Tang,1,* Yunzhao Zhao,2,* Weiwei Nie,1 Zexing Wang,1 Xiaoxiang Guan1 1Department of Medical Oncology, 2Department of General Surgery, Jinling Hospital, Nanjing University School of Medicine, Nanjing, People’s Republic of China *These authors contributed equally to this work Background: Prohibitin 3′ untranslated region 1630 C>T (rs6917) polymorphism creates a variant T allele that lacks the antiproliferative activity of the more common functional C allele. Previous studies indicate that women carrying the Prohibitin T allele have an increased susceptibility to breast cancer. However, the role of 1630 C>T polymorphism in mRNA expression of prohibitin and its contribution to carcinogenesis in the breast remains controversial. Methods: Using mRNA expression data from the HapMap online database, we sought an association between prohibitin 1630 C>T polymorphism and its mRNA expression, then conducted a meta-analysis of prohibitin 1630 C>T polymorphism and risk of breast cancer. Results: Although no significant association was found between prohibitin 1630 C>T polymorphism and mRNA expression in lymphoblastoid cell lines from the HapMap database (Ptrend = 0.543), the present meta-analysis involving 5072 cases and 4796 controls demonstrated that prohibitin 1630 C>T polymorphism was significantly correlated with breast cancer risk in allele contrast model T versus C (odds ratio [OR] 1.09, 95% confidence interval [CI] 1.01–1.18), the homozygote codominant model TT versus CC (OR 1.47, 95% CI 1.12–1.92), and the recessive model TT versus CC/CT (OR 1.45, 95% CI 1.10–1.89). Conclusion: Our study indicates that minor allele T of prohibitin 1630 C>T polymorphism is associated with increased susceptibility to breast cancer.