Profile of bosutinib and its clinical potential in the treatment of chronic myeloid leukemia

ofile of bosutinib and its clinical potential in the treatment of chronic myeloid leukemia Review (465) Total Article Views Authors: Keller-von Amsberg G, Koschmieder S Published Date March 2013 Volume 2013:6 Pages 99 - 106 DOI: http://dx.doi.org/10.2147/OTT.S19901 Received: 27 September 2012 Accepted: 01 November 2012 Published: 04 March 2013 Gunhild Keller-von Amsberg,1 Steffen Koschmieder2 1Department of Hematology and Oncology, University Cancer Center Hamburg, University Hospital Hamburg Eppendorf, 2Department of Medicine (Hematology, Oncology, and Stem Cell Transplantation), University Medical Center of Aachen and RWTH Aachen University, Aachen, Germany Abstract: Bosutinib (SKI-606) is an orally available, once-daily, dual Src and Abl kinase inhibitor with promising clinical potential in first-, second-, and third-line treatment of chronic myeloid leukemia (CML). Bosutinib effectively inhibits wild-type BCR-ABL and most imatinib-resistant BCR-ABL mutations except for V299L and T315I. Low hematologic toxicity is a remarkable characteristic of this novel second-generation tyrosine kinase inhibitor, and this has been ascribed to its minimal activity against the platelet-derived growth factor receptor and KIT. Low-grade, typically self-limiting diarrhea, which usually appears within the first few weeks after treatment initiation, represents the predominant toxicity of bosutinib. Other treatment-associated adverse events are mostly mild to moderate. Bosutinib has been approved by the US Food and Drug Administration for the treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive CML in adult patients with resistance or intolerance to prior therapy. This review summarizes the main properties of bosutinib and the currently available data on its clinical potential in the treatment of CML.