Integrative systems of genomic risk markers for cancer and other diseases: future of predictive medicine

tegrative systems of genomic risk markers for cancer and other diseases: future of predictive medicine Perspectives (11388) Total Article Views Authors: Yuzhalin AE, Kutikhin AG Published Date May 2012 Volume 2012:4 Pages 131 - 135 DOI: http://dx.doi.org/10.2147/CMAR.S30855 Received: 14 February 2012 Accepted: 09 April 2012 Published: 23 May 2012 Arseniy E Yuzhalin, Anton G Kutikhin Department of Epidemiology, Kemerovo State Medical Academy, Kemerovo, Russian Federation Abstract: This paper focuses on genomic predictive biomarkers in medicine. It is known that single nucleotide polymorphisms of genes involved in the pathogenesis of various diseases, including cancer, can serve as indicators of risk warranting further diagnostics, screening, and early prevention measures. However, although ten million single nucleotide polymorphisms have been identified to date, the majority of them do not appear to have a relationship with risk of development of pathogenic processes in the human body. The concept of selection of significant disease-associated biomarkers is proposed. Also, future development of integrative systems of genomic risk markers is discussed.