Diagnosis of carotid artery stenosis with oculopneumoplethysmography alone and in combination with MRA

gnosis of carotid artery stenosis with oculopneumoplethysmography alone and in combination with MRA Original Research (802) Total Article Views Authors: Elias RM, Wald JT, Kallmes DF Published Date November 2012 Volume 2012:8 Pages 631 - 639 DOI: http://dx.doi.org/10.2147/VHRM.S35041 Received: 15 June 2012 Accepted: 23 July 2012 Published: 23 November 2012 Richard M Elias,1 John T Wald,2 David F Kallmes2 1Department of Internal Medicine, 2Department of Radiology, Mayo Clinic, Rochester, MN, USA Background: The purpose of this study was to assess the accuracy of oculopneumoplethysmography (OPG) for the diagnosis of carotid artery stenosis both alone and in conjunction with carotid magnetic resonance angiography (MRA). Methods: This retrospective study reviewed patients who had undergone both OPG and digital subtraction angiography (DSA, 90 patients, 174 vessels) within two weeks to determine the accuracy of OPG with DSA as the reference standard for the detection of carotid artery stenosis. Three carotid artery stenosis thresholds (≥50%, ≥70%, ≥80%) were analyzed. The accuracy of the combination of OPG and MRA was analyzed in a subset of patients who underwent OPG and MRA and DSA (53 patients, 94 vessels). Results: The sensitivity and negative predictive value of OPG increased with higher-degree carotid artery stenoses, and for lesions ≥ 80%, these values were 85.3% and 94.2%, respectively. Specificity and positive predictive values were lower at all thresholds, and were 72.9% and 49.3%, respectively, at the ≥80% stenosis threshold. When OPG and MRA were concordant, the sensitivity and specificity for carotid artery stenoses ≥ 80% were 91.0% and 97.8%, respectively. OPG correctly identified 71.4% of false-positive and 80.0% of false-negative magnetic resonance angiographies for that degree of carotid artery stenosis. Conclusion: OPG appears to be an accurate rule-out test for hemodynamically significant carotid artery stenosis. OPG augments the accuracy of MRA for detection of carotid artery disease.