Topical azithromycin or ofloxacin for endophthalmitis

Topical azithromycin or ofloxacin for endophthalmitis Letter (1336) Total Article Views Authors: Stewart MW, Stewart ML Published Date December 2012 Volume 2013:7 Pages 35 - 38 DOI: http://dx.doi.org/10.2147/OPTH.S39234 Received: 16 October 2012 Accepted: 16 October 2012 Published: 04 January 2013 Michael W Stewart, Michael L Stewart Department of Ophthalmology, Mayo Clinic, Jacksonville, FL, USA The recently published study by Romero-Aroca et al1 raises interesting questions regarding the effect of choice of topical antibiotic (azithromycin versus ofloxacin) on the incidence of endophthalmitis following intravitreal injections. However, important conclusions advanced by the authors deserve further discussion. First, the authors state that use of azithromycin leads to significantly fewer cases of post-injection endophthalmitis than does the use of ofloxacin. Their prospective series shows a lower endophthalmitis rate in eyes treated with azithromycin (two cases in 4045 injections, 0.049%) than in eyes treated with ofloxacin (five cases in 4151 injections, 0.12%). They calculate a relative risk of 2.37, and conclude that this was statistically significant (confidence interval 1.37–3.72; P < 0.001). View original paper by Romero-Aroca and colleagues. Post to: Cannotea Citeulike Del.icio.us Facebook LinkedIn Twitter Other articles by Dr Michael Stewart A retrospective cohort study of clinical outcomes for intravitreal crystalline retained lens fragments after age-related cataract surgery: a comparison of same-day versus delayed vitrectomy Clinical and differential utility of VEGF inhibitors in wet age-related macular degeneration: focus on aflibercept Optimal management of cytomegalovirus retinitis in patients with AIDS Readers of this article also read: Ultrasonic lateral modulation imaging, speckle reduction, and displacement vector measurements using simple single-beam scanning or plural crossed-beam scanning with new spectra frequency division processing methods A characteristic optic disc appearance associated with myopia in subjects with Graves' ophthalmopathy and in subjects with primary open-angle glaucoma Comparison of different intraocular pressure measurement techniques in normal eyes, post surface and post lamellar refractive surgery Comparative analysis of corneal morphological changes after transversal and torsional phacoemulsification through 2.2 mm corneal incision Argon laser peripheral iridoplasty versus systemic intraocular pressure-lowering medications as immediate management for acute phacomorphic angle closure Diabetic and non-diabetic human cornea and tear γ-glutamyl transpeptidase activity Navigated macular laser decreases retreatment rate for diabetic macular edema: a comparison with conventional macular laser Safety of besifloxacin ophthalmic suspension 0.6% in refractive surgery: a retrospective chart review of post-LASIK patients Exacerbation of signs and symptoms of allergic conjunctivitis by a controlled adverse envir