OnabotulinumtoxinA in the treatment of neurogenic bladder

abotulinumtoxinA in the treatment of neurogenic bladder Review (1607) Total Article Views Authors: Gulamhusein A, Mangera A Published Date August 2012 Volume 2012:6 Pages 299 - 306 DOI: http://dx.doi.org/10.2147/BTT.S30180 Received: 04 July 2012 Accepted: 07 August 2012 Published: 28 August 2012 Aziz Gulamhusein, Altaf Mangera Department of Urology Research, Sheffield Teaching Hospitals NHS Trust, Royal Hallamshire Hospital, Sheffield, United Kingdom Abstract: This review examines the evidence for use of onabotulinumtoxinA in the treatment of neurogenic lower urinary tract dysfunction. Since its first use in 1988 to treat detrusor sphincter dyssynergia, use of botulinum toxin has increased in this group of patients. We discuss the mechanism of action, patient selection, dosing, efficacy, and side effect profile of this now licensed treatment option.