Biocompatibility and Gene Expression Associated with Streptococcus Infection in Myocarditis

Myocardial inflammation is a nonspecific response to various triggers such as viral and bacterial infection. This study was designed to examine the Streptococcus induction of myocarditis in rat and induction of CRP, SAP, LBP and Cytokines on the transcriptional activity of the inflammation / related genes expression using a semi-quantitative RT-PCR in liver and heart tissues. Experimental myocarditis was established with intra-peritoneal injection of 108 CFU/ ml of Streptococcus faecalis in three groups of rats and sacrificed after one, two and seven days post infection, respectively. Heart and liver functions were highly elevated while kidney functions were not affected. Histopathological examination for heart and liver showed damage effect for the bacterial infection. Expression pattern of CRP, SAP, LBP & IL6 genes were investigated, in liver these genes were highly expressed while some of them showed no expression pattern in heart tissues.