Adiponectin, IL-10, IL-23 and Trace Elements Serum Levels in Patients with Psoriasis

Psoriasis is a multifactorial, chronic, inflammatory skin disease of unknown aetiology, associated with cytokines and adipokines serum levels changes that may influence disease pathogenesis. A case control study was performed to determine the serum levels of IL-10, IL-23, adiponectin, Zn, Mg and Cu in psoriasis patients. IL-10 and IL-23 mean serum level were higher in psoriatic patients than in control. Moderate and severe cases of psoriasis were with lower serum IL-10 mean level as that in mild form of disease and controls. Mean IL-23 serum level was significantly higher in obese psoriatic patients than in psoriatic patients with BMI <25 and in control individuals with BMI of >25. Serum levels of IL-23 highly significantly negatively correlated with disease duration. An interesting finding of this study was that serum zinc levels were significantly negatively correlated with BMI and the correlation coefficient was more in psoriatic obese or overweight patients (with BMI >25). A highly significant positive correlation between zinc serum levels in psoriatic patients and serum adiponectin levels. A significant correlation demonstrated between IL-10 & IL-23; Mg & IL-23; Adiponectin & BMI; Zn & Cu. Our findings indicated the influence of obesity and disease severity on psoriasis markers.