Pattern of Weight Changes Amongst Non-Psychotic Depressive Subjects on Amitriptyline Treatment

This study investigated the pattern of changes in Weight and Body Mass Indices changes among 25 Non-psychotic Depressives on daily 50 mg of Amitryptilline, who were age and sex matched with the control group. Diagnosis was based on DSM (IV) (1994). Measurements of Weight and Body Mass Indices (BMI) after 2 and 6 weeks from the commencement of the study showed significant differences. The result suggests that amitryptilline is associated with weight gain and increased BMI in Nigerian Africans with non-psychotic depression.