Template-Based Protein Structure Prediction
基于模板的蛋白质结构预测

Methods for predicting three-dimensional structure of protein molecules can be classified into two categories: template-based modeling and template free modeling. Template-based prediction is widely used in application due to its speed and relatively high accuracy. This technique predicts the three-dimensional structure of a given protein sequence based primarily on its alignment to one or more proteins of known structure. In this paper, the progress in the methodology for template-based modeling is reviewed. The critical steps and factors that influence the prediction accuracy are analysed and discussed.