Developmental Toxicity of Perfluorooctane Sulfonate (PFOS) and Its Substitutes to Amphibian Embryos
全氟辛烷磺酸盐(PFOS)及其替代品对两栖类胚胎的发育毒性

In this study, the developmental toxicity of perfluorooctane sulfonate (PFOS) and its four substitutes on Xenopus laevis embryos and Rana nigromaculata embryos studied comparatively. It was found that tri-fabric finishing agent synthetized using telomerization method (tri-fabric finishing agent) and 50% perfluorobutyl organic ammonium salt cationic surfactant (50% cationic surfactants) as well as PFOS had obvious toxicity to X. laevis embryos. Moreover, the toxicity of tri-fabric finishing agent and 50% cationic surfactant was significantly higher than that of PFOS. C4 and C6 tri-proof finishing agent (C4 and C6) synthetized by electrolysis fluorination method were not toxic to X. laevis embryos. To R. nigromaculata embryos, PFOS and four substitutes had no obvious toxicity. In term of biological safety, these results show that C4 and C6 might be used as the substitutes for PFOS, while tri-fabric finishing agent and 50% cationic surfactant should be considered carefully.