Can We Determine a Protein Structure Quickly?

Can we determine a high resolution protein structure quickly, say, in a week? I will show this is possible by the current technologies together with new computational tools discussed in this article. We have three potential paths to explore: X-ray crystallography. While this method has produced the most protein structures in the PDB (Protein Data Bank), the nasty trial-and-error crystallization step remains to be an inhibitive obstacle. NMR (Nuclear Magnetic Resonance) spectroscopy. While the NMR experiment...