Synthesis of heptakis(2,3,6-tri-O-methoxymethyl)-β-cyclodextrin and its application in gas chromatography
七(2,3,6-三-O-甲氧甲基)-β-环糊精的合成及其在气相色谱分离中的应用

A new chiral stationary phase for gas chromatography, heptakis(2,3,6-tri-O-methoxymethyl)-β-cyclodextrin, was synthesized by substituting the 2,3,6-OH groups of β-cyclodextrin with methoxymethyl groups, and a coated capillary column for gas chromatography was made by coating this new stationary phase with static method. The chromatographic properties and separation abilities of the prepared stationary phase were studied. The test results showed that it possessed good separation abilities to Grob test mixture, disubstituted benzene isomers (e.g. nitrotoluenes, bromotoluenes, dichlorobenzenes, dimethylbenzenes) and some chiral compounds such as methyl 2-hydroxypropionates, ethyl 2-hydroxypropionates, methyl 2-methylsulfonylpropionates. The comparison of chiral separation results between 2,3,6-tri-O-methoxymethyl-β-cyclodextrin and 2,3,6-tri-O-methyl-β-cyclodextrin showed that the separation abilities of the two stationary phases were different and complementary to each other for some chiral ester enantiomers.