Sustained low-efficiency dialysis in surgical acute kidney injury - really useful?

According to the protocol (NCT00322530), the authors aimed to enroll 100 patients per group, a sample size that may be justified only for an anticipated (but unlikely) mortality difference of roughly 20%. Thus, the present study is clearly underpowered to detect differences in the primary outcome (90-day mortality).Unfortunately, neither baseline pulmonary function nor indications for respiratory support are presented. This leaves ample room for speculation that - in such a small population with a high percentage of patients for whom severe pulmonary complications are common - the shorter duration of ventilator support in the SLED group may be related to factors other than the RRT modality.Despite the protocol (NCT00322530), the authors do not present renal recovery at 90 days. 'Time after RRT initiation' is a questionable renal outcome taking into account the lack of clearly defined RRT stop criteria and the unusual use of high-dose diuretics during (!) RRT.With respect to these and other [2] limitations of the present study and the continuous RRT benefits shown in a recent meta-analysis [3], adequately powered studies comparing SLED and continuous venovenous hemodiafiltration are still urgently needed.Vedat Schwenger, Markus Weigand and Christian MorathWe thank Heringlake and colleagues for their comments. Indeed, our study has several limitations that had been addressed thoroughly in the Limitations section of our article: 'the power of the study may be probably insufficient to finally judge whether one or the other treatment modality is superior in terms of survival' [1]. However, with comparable efficacy and safety of SLED and CVVH, the question comes down to economics, and the power of our study was clearly sufficient to discriminate differences in economics in favor of SLED therapy. Therefore, according to the best available evidence we have, dialysis techniques such as SLED are not inferior to continuous RRTs but do cost significantly less [1,4-6].As discuss