Effectiveness and Efficiency of Assertive Outreach for Schizophrenia in Germany: study protocol on a pragmatic quasi-experimental controlled trial

Quasi-experimental controlled trial: patients receiving the intervention are all those receiving AO; controls are patients not eligible for AO due to their health insurance affiliation. Eligibility criteria: clinical diagnosis of schizophrenia (ICD-10 F.20), aged at least 18 years and being moderately to severely impaired in global functioning. Primary outcome: admission and days spent in psychiatric inpatient care; secondary outcomes: clinical and functional status; patient satisfaction with chronic care; health care costs. Follow-up time: 6 and 12 months.The study faces many challenges typical to pragmatic trials such as the rejection of randomisation by service providers, the quality of treatment as usual (TAU) to which the intervention will be compared, and the impairment of the study subjects. Solutions of how to deal with these challenges are presented and discussed in detail. Trial registration: International Standard Randomised Controlled Trial Number: ISRCTN34900108, German Clinical Trial Register: DRKS00003351