The effect of Camellia Sinensis (green tea) mouthwash on plaque-induced gingivitis: a single-blinded randomized controlled clinical trial

Complementary medicine received high attention during last decades. We aimed to assess the efficacy of Green tea mouthwash on plaque-induced gingivitis as the most common form of periodontal disease.We designed a single blinded placebo controlled clinical trial. High school female students with chronic generalized plaque-induced gingivitis were distributed to receive either 5？ml of Green tea 5% two times/day or normal saline with the same dosage. Gingival index (Sillness & Loe), plaque index (Sillness & Loe) and bleeding index (Barnett) were recorded at baseline and five consecutive weeks. Comparisons were made by a general linear model, repeated measure ANOVA and a Bonferroni test applied for multiple comparisons.Twenty five students were recruited in each arm of the study. A significant improvement was observed in all periodontal indices during the study (P？<？0.001). Two groups were contrasted by changing patterns of alteration of indices (P？<？0.05). Although total amount of improvement was higher in mouthwash group, the differences did not reach a statistically significant level (P？>？0.05, observed power for GI: 0.09, PI: 0.11 and BI: 0.07).Green tea mouthwash may be a safe and feasible adjunct treatment for inflammatory periodontal diseases. A future larger scale study is warranted for better evaluating the effect of green tea.Gingivitis and periodontitis, as the multifactorial diseases, are mainly derived by interaction between invasions of causative bacteria and host immune response of varied degrees [1]. Plaque induced gingivitis is the most common form of gingivitis and is induced by accumulation of microbial plaque containing more than 300 types of bacterial species [2]. Historical periodontal treatment dates back to 30B.C, when vinegar was applied to cure periodontal diseases. Over the time, more specific treatment modalities were developed, including scaling and root planning (SRP) and surgical techniques [2].Complementary medicine received a great attent