Short-term efficacy of intravitreal dobesilate in central serous chorioretinopathy

This is an interventional case report in which dobesilate was intravitreally injected in a case of recurrent CSC. Main measures included fundoscopy, Snellen visual acuity (VA) testing, fluorescein angiography and optical coherence tomography (OCT).We present anatomical and functional evidences, obtained as early as eleven days after the treatment, of the efficacy of intravitreal dobesilate, in the treatment of chronic CSC condition. The effect after intravitreal dobesilate injection for CSC might be related to the normalization of retinal architecture.Intravitreal dobesilate may be an effective treatment option for recurrent CSC.Central serous chorioretinopathy (CSC) is a well-characterized self-limiting disorder leading to serous neurosensory elevation of the retina. The acute form of the disease in many patients resolves spontaneously, with residual subjective impairment mainly in the form of faint scotomas or metamorphopsia [1]. Those patients who do not resolve spontaneously can develop chronic CSC with retinal pigment epithelium (RPE) and photoreceptor damage, resulting in permanent visual impairment.The pathophysiology of CSC remains poorly understood. However, the cascade of events leading to neurosensory detachment includes, and may in fact begin with changes in choroidal permeability [2]. We recently reported that dobesilate, a well-characterized fibroblast growth factor (FGF) inhibitor [3] abolished vascular endothelial growth factor (VEGF)-driven vascular hyperpermeability and fluid leakage [4].CSC was first described by von Graefe in 1866. CSC is a condition commonly seen in young or middle age adults as a localized detachment of the neurosensory retina in the macular region [5,6]. In acute CSC with focal leakage, RPE increases its function to absorb the subretinal fluid and the disease is self limiting. However, in those cases with persistent focal or chronic diffuse leakage, RPE may decompensate and thus gradually lead to a less favourable prognosis wi