NATURAL POLYMER VIS A VIS SYNTHETIC POLYMER FOR SOLUBILITY ENHANCEMENT OF SIMVASTATIN

The enhancement of the oral bioavailability is currently one of the greatest challenges in the development of poorly water soluble drugs. The main objective of work to enhance solubility of Simvastatin (SIM) by use of natural polymer, chitosan (CHI) and Hydroxy propyl methyl cellulose E3LV (HPMCE3LV), synthetic polymer to produce cost effective formulation. Physical mixture, co-grinding method, spray drying method are compared for solubility enhancement of simvastatin. It is found that co-grinding method is best for solubility enhancement of simvastatin.Co-grinding method applied for preparation of drug polymer complex and compared with the solubility and dissolution of marketed preparation.