FORMULATION AND EVALUATION OF MATRIX DIFFUSION CONTROLLED TRANSDERMAL DRUG DELIVERY SYSTEM OF GLIPIZIDE

There has been a tremendous increase in interest for transdermal drug delivery system for sustain release dosage form in chronic manageable diseased conditions like diabetes, hypertension etc to reduce the frequency of dosing. It reduces the risk of exposing the body to drug above maximum safe concentration in case of dosage form failure in comparison to oral sustained release drug delivery system. It also reduces the frequency of dosing and improves patient compliance. Transdermal patches of Glipizide were formulated to achieve sustain release pattern within the therapeutic range. HPMC 5cps, HPMC 15cps, HPMC K-100M, Ethyl cellulose (EC), Eudragit RS 100 (ERS-100) and Polyvinylpyrrolidone (PVP) K30 were used as matrix forming polymer. Propylene glycol was used as penetration enhancer. Polyethylene glycol (PEG) 400 and n-dibultyl phthalate (n-DB) were used as plasticizer. Methanol and chloroform were used as solvents. Patches were prepared by solvent casting method. Prepared patches were evaluated for physicochemical parameters like weight variation, thickness, folding endurance, drug content, % moisture absorption and % elongation break test. Patches prepared, from each batch, gave release profile for over 10 hours. Cumulative amount of drug release in 12 hours from all the prepared formulations were found to be in following order: F1 > F3 > F4 > F10 > F9 > F6 > F8 > F7 > F2 > F5 > F11 > F12. Prepared patch from HPMC 5 cps and ethyl cellulose (F1) exhibited good characteristics for sustained release action and other parameters evaluated