Comparison of Cord Blood Atherogenic Index in Males and Females

Background: A strong independent relationship has been observed in epidemiological studies between serum cholesterol and coronary heart disease.Method: Study group consisted of 100 healthy newborns and hundred healthy volunteers (age group 18-25 years) served as controls. Samples were analyzed for lipid profile (total cholesterol, triglycerides, HDL cholesterol, VLDL cholesterol, and LDL cholesterol), apolipoproteins: ApoA-I, ApoB. Atherogenic index (A.I.) was calculated as ratio of Apo-B to ApoA-I. Results: Lipid profile parameters were significantly lower in cord blood as compared to adults (P<0.001), cord blood of female newborns had higher total cholesterol (T-C), HDL-C, LDL-C Apo A-I, Apo B and A.I. as compared to male newborns, whereas triglycerides and VLDL–C were higher in male newborns. Conclusion: Gender-related factors might influence lipid levels and the pathological processes for CVD and its risk factors have been rooted in childhood which can change favorably in youth with lifestyle modifications and obesity reduction.