Effect of Colloid versus Crystalloid Administration of Cardiopulmonary Bypass Prime Solution on Tissue and Organ Perfusion

Background: We evaluated the effects of tissue and organ perfusionduring and after coronary artery bypass graft surgery with either colloid(Voluven) or crystalloid (Lactated ringer’s) as prime solution.Methods: In this prospective randomized-controlled trial study, 70patients undergoing on-pump coronary artery bypass graft surgery were randomlyassigned to receive either colloid (Voluven) or crystalloid (Lactated ringer’s)as prime solution, for initiation of cardiopulmonary bypass machine procedure.Tissue and organ perfusion markers including lactate, troponin I, liver andrenal function tests and electrolytes were measured sequentially, beforeinduction (T1) to second days after surgery (T5).Results: With exception of chloride and potassium levels no significantdifferences detected in other measurements, and the laboratory results wereentirely identical in both procedures.Conclusion: There was no significant difference between Voluven (hydroxyethyl starch, HES 130/0.4) and crystalloid (Lactated ringer’s) as primingsolution on the basis of organ and tissue perfusion tests assessment.