Physical evaluations of Haruan spray for wound dressing and wound healing

Haruan spray (aerosol) dosage form is a new dosage form formulated for use as wound dressing and wound healing. Spray can minimize pain and emotional trauma experience during the application and removal process of conventional dressing and bandages. Haruan extract is incorporated as an active ingredient of the aerosol concentrate for its ability to enhance the healing process. The aim of this study is to evaluate the physical properties of Haruan spray using different propellant. The propellants evaluated were 1,1,1,2 – tetrafluoroethane (HFA 134a), butane and propane. Concentrate of aerosol also contain hydroxypropyl methylcellulose (HPMC) as polymer and glycerine as plasticizer. All ingredients of the aerosol were packaged in an aluminium container fitted with continuous-spray valves. Evaluations for the Haruan spray included delivery rate, delivery amount, pressure, minimum fill, leakage, flammability, spray patterns and particles image. Glass containers were used to study incompatibility between the concentrate and propellant due to the ease of visible inspection. HFA 134a reacted with the concentrate and produced white aggregates, while propane had a very high vapour pressure. From safety and economics point of view, butane was chosen as the propellant because it met the requirements for aerosol and produced Haruan spray with the expected characteristics. Keywords: Aerosols; Haruan; 1,1,1,2 – tetrafluoroethane (HFA 134a); propane; butane; aluminium canister