Postoperative cognitive disfunctions and necessity of analgosedation

We observed and noted clinical symptoms, and used screenig tests as tools for evaluating the values of pain and neuropsychiatric changes. We introduced as instrument of measurements: rating numerologic scale of pain, Ramsay Sedation Scale (RSS), criteria of delirium diagnose applied in early period of arrousal (20 minutes - 4 hours) at the moment T1, at 4-7 hours: complete arrousal (T2) and at 72 hours (T3). We tried to correlate the results of answers to these questionnaires to EEG aspects, auditory evoked potentials (AEP), with morphopathologic and biochemical aspects characteristic for the evolution toward wounds healing. We selected 100 patients from the Plastic and Recontructive Surgery Department. We associated to those moments the functional values: arterial pressure, central pulse, diuresis, respiratory frequency, (to evaluate the autonomic nervous sistem implication) and laboratory parameters oxidants/antioxidant values (free O2 radicals as peroxides, NO, capacity antioxidant of plasma (CAO) and superoxide dismutase (SOD), for evaluating the implication of oxidative stress in postoperative evolution. All values were compared among them and correlated with morphopathological aspects from optic microscopy, from biopsies prelevated immediately after the postoperative period and at the end of postoperative wounds healing. The most important conclusion of our study was that: appropriate information of patients about surgery and anesthesia reduces preoperative anxiety, post-operative pain and hospital stay length.