An atom efficiency, solvent-free synthesis of some new heterocyclic imines and antibacterial activity

A solvent-free condensation of substituted aryl amines with indole-3-aldehyde in presence of catalytic amount of acetic acid at room temperature in combination with grinding to yield new series of heterocyclic imines (Schiff bases). The simple reaction procedure, short reaction time, no need of organic solvent and high yields make this protocol practical and economically attractive.