Sinthetic study of some beta-aminoketones using thiazolidine as catalyst

Mannich reaction is one of the most widely used in organic chemistry. In this reaction, there is a insertion of a aminomethyl group on the α position to the carbonyl group. Such reaction has numerous applying in organic chemistry in the synthesis of product with biological interest, such as analgesics and antibiotics. To form the Mannich’s bases a catalyst is needed and, with this purpose, the thiazolidines were used. Thiazolidines are cyclic compounds of five members which contain on the position 1 the sulphur atom and on the position 3 the nitrogen one. All the reactions were carried out at room temperature involving cyclopetanone, formaldehyde and various imines (aniline, p-chloroaniline and p-toluidine) (Scheme 1). The products of interest were satisfactorily obtained and their structures were confirmed through spectrometric methodologies.