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Synthesis of 2-(4-Aminomethyl-1H-1,2,3-Triazole-1-yl)-1,4-Naphthoquinone Derivatives Síntese de derivados de 2-(4-aminometil-1H-1,2,3-triazol-1-il)-1,4-naftoquinonaKeywords: 1 , 2 , 3-triazol , 2-aminometil , 1 , 4-naftoquinona , cicloadi o Abstract: In this work, were synthesized 18 new compounds based on 1H-1,2,3-triazole-1,4-naphthoquinones via Cu-AAC (Cu-catalyzed Azide Alkyne Cycloaddition) reaction. The compounds (2-7)(a-c) were obtained in moderate-to-good yields (43-99%). Two methodologies were employed to obtain 2-(4-aminomethyl-1H-1,2,3-triazol-1-yl)-1,4-naphthoquinone derivatives. Firstly, we using the Method A (CH3CN/CuI/r.t./20h), but some compounds presented moderate yields of 43-60%. Fortunately, when we applied the Method B (DMF/Et3N/ultrasound), were obtained yields between 78 and 92%. Neste trabalho, foram sintetizados 18 compostos novos baseados na estrutura de 1H-1,2,3-triazóis-1,4-naftoquin nicos via rea o Cu-AAC “Cu-catalyzed Azide Alkyne Cycloaddition” (Esquema 1). Os compostos (2-7)(a-c) foram obtidos em rendimentos de moderados a bons (47-99%). Duas metodologias foram utilizadas para obter os derivados da 2-(4-aminometil-1H-1,2,3-triazol-1-il)-1,4-naftoquinona. Primeiramente, usamos o método A (CH3CN/CuI/t.a./20h), mas alguns compostos apresentaram moderados rendimentos de 43-60%. Felizmente, quando aplicamos o Método B (DMF/Et3N/ultrassom), foram obtidos rendimentos entre 78 e 92%.
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