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A chiral 1,3,2-dioxaborolane derived from a natural diterpene for asymmetric reduction of prochiral ketonesKeywords: Asymmetric reductions , chiral 1 , 3 , 2-dioxaborolane , 2 a , 3 a -dihydroxycativic acid. Abstract: The application of a chiral 1,3,2-dioxaborolane, for the sulfide complex-mediated asymmetric reduction of prochiral ketones at room temperature, are described. The B-methoxy-dioxaborolane was synthesized from 2 a ,3 a -dihydroxycativic acid, a labdane-type diterpene isolated from aerial parts of Baccharis scandens DC. Very good chemical yields (85-97%) and high enantioselectivities (62-96% ee), were obtained.
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