Metabolic Syndrome in the Immediate Female Relatives (Mothers) of Women with Polycystic Ovarian Syndrome

Introduction: About 40% of PCOS affected women’s sisters have hyperandrogenemia and are exposed to metabolic syndrome risk. This study aimed at investigating metabolic disorders and level of testosterone in immediate relatives (mothers) of patients with polycystic ovarian syndrome. Methods: The study was conducted over 34 mothers of patients with polycystic ovarian syndrome, and 34 relatives of women without the syndrome. Blood pressure, height and weight, a blood sample were obtained from all participants in order to investigate their serum insulin, blood sugar, testosterone and lipoproteins. Metabolic syndrome was evaluated based on ATPIII (Adult Treatment Panel Ш) and IDF (International Diabetes Federation), and resistance to insulin was evaluated based on HOMA indices (Homeostasis Model Assessment Index) and QUICKI (Quantitative Insulin Sensitivity Check Index) and fasting blood sugar and BMI≤30kg/m2. Results: The prevalence of metabolic syndrome in mothers of the PCOS was according to ATPIII index and IDF index was not significantly different from the relatives of healthy group (P>0.05). The means of fasting blood sugar, blood pressure, serum testosterone, total cholesterol, LDL. HDL and triglyceride in mothers of the healthy women were very different from those of the mothers of the patients (P<0.05). Central obesity was not significantly different in the two groups (P>0.05). Conclusion: Immediate relatives especially mothers of women suffering from polycystic ovarian syndrome are exposed to metabolic syndrome.