Local Therapy of Gonarthrosis Using Autologous Platelet-enriched Plasma

The aim of the investigation is to assess clinical effect of local (intra-articular) application of autologous platelet-enriched plasma (PEP) in treating gonarthrosis. Materials and methods. Clinical observation of 83 women with gonarthrosis was performed within 3 months. Within 3 weeks the patients were receiving PEP intra-articular injections of 5 ml twice a week. Results. In intra-articular PEP administration in patients with gonarthrosis, the change of knee joint functional state occurs depending on the severity of osteoarthrosis, the most significant change — in the early stage and almost absent change in severe diseases (complicated by synovitis). In typical gonarthrosis of II–III radiological stages, the positive effect is short-term and observed in early one-month observation period.