Genetic association of selected microsatellite with some metabolic syndrome components in Iranian Fars and Azari families

Introduction: Family base association test (FBAT) is widely used in study of genetic association ofallele of genetic markers and different phenotype for locating genes locus. The present study attempted toinvestigate the genetic association of some candidate microsatellites with HDL-C, triglyceride, and waist inorder to find chromosomal area locus of effective genes in metabolic syndromes in Persian and Azaripeople of Iran.Materials and Methods: in this study 107 families were selected from participants in Tehran Lipid andGlucose Study. Each family had at least one member with metabolic syndrome (according to ATP III) andat least two members with reduced HDL-C level. The genetic association of HDL-C, triglyceride, and waistwith some candidate microsatellites in chromosome 8, 11, 12, and 16 was studied using FBAT.Results: the data covered 107 families consisting of 483 individuals. For Persian individuals, study ofChromosome 8 revealed significant association between D8S514 and HDL-C and between D8S1743 andtriglyceride (P<0.05). For Azari individuals, association of D8S1132 and D8S1743 in Chromosome 8 toHDL-C was significant (P<0.05).Discussion: FBAT is robust against confounders such as misspecification of genetic models andpopulation stratification. By finding microsatellites affecting HDL-C, triglyceride, and waist, the resultsfound in this study may be helpful in determining predisposing genes in metabolic syndrome.