Evaluation of antibacterial activity of silver nanoparticles against MSSA and MRSA on isolates from skin infections

In recent years, skin and soft-tissue infections (SSTIs), particularly due to multidrug-resistant pathogens areincreasingly being encountered in clinical settings. Due to the development of antibiotic resistance and theoutbreak of infectious diseases caused by resistant pathogenic bacteria, the pharmaceutical companies and theresearchers are now searching for new unconventional antibacterial agents. Recently, in this fieldnanotechnology represents a modern and innovative approach to develop new formulations based on metallicnanoparticles with antimicrobial properties. The bacterial growth curve, minimum inhibitory concentration (MIC),and minimum bactericidal concentration (MBC) of silver nanoparticles (Ag-NPs) towards Staphylococcus aureusATCC25923, methicillin-sensitive S. aureus (MSSA), and methicillin-resistant S. aureus (MRSA) were examinedin this study. The experiment results showed that the lowest MIC and MBC of Ag-NPs to MRSA was 12.5 μg/mland 25 μg/ml, respectively. The obtained results suggested that Ag-NPs exhibit excellent bacteriostatic andbactericidal effect towards all clinical isolates tested regardless of their drug-resistant mechanisms.