Chemoprotective activity of hydro-ethanolic extract of Euphorbia neriifolia Linn leaves against DENA-induced liver carcinogenesis in mice

Liver cancer is one of the leading causes of cancer death worldwide. This idea has prompted to evaluate thehepatoprotective properties of hydro-ethanolic extract of Euphorbia neriifolia (EN) Linn against N-Nitrosodiethylamine(DENA) induced liver cancer in mice. Male mice were pre-administered with EN extract (150 and 400 mg/kg bodyweight; p.o.) and standard (0.5% BHA) prior to single dose of DENA (50 mg/kg body weight; p.o.). Various in vivobiochemical parameters like lipid peroxidation, superoxide dismutase and catalase were evaluated to determine thehepatoprotective and antioxidant activity of EN. DENA significantly increased LPO and decreased the endogenousantioxidant enzymes (SOD and CAT). The EN extract significantly restored the antioxidant enzyme level in the liverand exhibited significant dose dependant protective effect against DENA induced liver toxicity, which can be mainlyattributed to the antioxidant property of the extract. This study rationalized the ethno-medicinal use of the EN forcuring liver cancer.