Ameliorative effect of Vitamin E on the deleterious effect of Amodiaquine hydrochloride (AQ.HCl) on the reproductive function of the adult cyclic Sprague-Dawley (S-D) rats

This study determined whether exogenous supplementation with Vitamin E could confer ameliorative effect againstthe deleterious effect of AQ.HCl on ovarian function of matured S-D rats. Thirty S-D rats divided into two groups wereused in this study: Group A – determined the effect of AQ.HCl 1 Vitamin E administered for 28 days on the oestrouscycle and antioxidant activities of superoxide dismutase (SOD) and catalase (CAT). Group B – determined the effectof a single dose of AQ.HCl 1 Vitamin E administered at 5 p.m. on proestrus on ovulation and serum concentrationsof follicle stimulating hormone (FSH), luteinizing hormone (LH), and prolactin (PRL). The exogenous supplementationwith Vitamin E increased (p  0.05) the length of the oestrous cycle and the diestrus phase, decreased the activitiesof CAT and SOD slightly, and did not hinder ovulation in adult S-D rats. Vitamin E proffered ameliorative effect againstthe deleterious effect of AQ.HCl through its antioxidant activity.