Immune diagnosis of human fasciolosis in children from Cajamarca, Perú

The immunodiagnostic potential of a FAST-ELISA for the detection of antibodies in fasciolosis with sera from 6-12 year old children from Cajamarca, Peru was examined. Four children negative parasitologically were negative by FAST-ELISA. All 13 children found positive parasitologically were also positive by FAST-ELISA for 100% sensitivity. Twelve of the 13 infected children seroreverted 4 months post dihydroemetine therapy showing lower antibody levels as compared with the pretreatment sample. These results suggest that FAST-ELISA may be useful for the determination of infection and success of therapy in children with fasciolosis. Se estudio el potencial inmunodiagnóstico de un FAST-ELISA para la detección de anticuerpos contra de fasciolosis en ni os de Cajamarca, Perú. Sueros de 4 ni os no infectados fueron negativos mientras que 13 ni os infectados fueron positivos a la prueba de FAST-ELISA. Doce de los ni os infectados serorevirtieron con disminución de anticuerpos cuatro meses luego de terapia con dehidroemetina. Estos resultados indican la utilidad de la prueba de FAST-ELISA para detección de infección y predicción de cura en ni os con fasciolosis.