WATER DISPERSIBLE METAL OXIDE NANOBIOCOMPOSITE AS A POTENTIATOR OF THE ANTIMICROBIAL ACTIVITY OF KANAMYCIN

This study reports the evaluation of a water dispersible metal oxide nanobiocomposite based CS and magnetite as a potential drug delivery system and its cytotoxicity. The results proved that loading kanamycin sulfate into the water dispersible metal oxide nanobiocomposite improve the delivery of this drug in active form reducing minimum inhibitory concentration of kanamycin by two (in case of S. aureus) to four folds (in case of E. coli), as compared with the kanamycin control. Furthermore, cytotoxicity test revealed that the nanobiocomposite has a very low toxic effect on eukaryotic cells. Our data suggest that water soluble metal oxide nanobiocomposite derivative is a good candidate for developing alternative strategies for enhancing the activity of antimicrobial drugs, without increasing the amount of the loaded active compound.