The new glial model

The management of clinical pain is a major challenge in health care and basic research.New protein structures involved in the transduction of pain such as thermalreceptors 'Transient Receptor Potential' (TRP), receptors of potential transition, that are non-selective cation channels, have been identified in recent studies. The inflammatory process lowers the threshold for activation of receptors TRP, which is normally active at higher body temperatures than the baseline. Recent studies have shown that the TRPV1 plays a role in the activation of the glia cord in the presence of nociceptive, inflammatory and neuropathic pain, through the activation of an action potential responsible for the release of neurotransmitters such as glutamate and CGRP in the dorsal horn. So, this process activates and supports the mechanism of chronic pain. A greater appreciation of the role of various mediators or mechanisms that activate microglia could help bring new therapeutic targets in the future and new efforts to improve the treatment of severe symptoms of chronic pain.