Comparative study of intrathecal hyperbaric Bupivacaine with Clonidine, Fentanyl and Midazolam for quality of anaesthesia and duration of post opera- tive pain relief in patients undergoing elective caesarean section

Pain free postoperative period and early ambulation are the need of the day for mothers caring for theirneonates.The use of adjuvants in spinal analgesia has gained popularity in recent times. This prospective randomizedstudy was carried out among 120 patients scheduled for elective caesarian section. They were divided into 4 groups.Group A (Control) received Injection Bupivacaine (Hyperbaric) along with 0.9% Normal saline, Group B, C and D receivedClonidine 75 μg, Fentanyl 25 μg and Midazolam 2.5 mg along with injection Bupivacaine (H) respectively.The results of the present study showed that intrathecal Clonidine, Fentanyl and Midazolam can be used safelyin parturient, provided strict protocol for preloading is followed by vigilant operative and post-operative monitoring bya trained person. Requirement of postoperative analgesics was found to be significantly reduced in all the study groupswhen compared with the control group. The highest duration of pain relief was found with Clonidine. Adverse effects wereminimal and could be easily managed; no adverse foetal effect was noted with the use of any drug in this study.