Immunohistochemical evaluation of transforming growth factor (TGF-b1) in malignant salivary gland tumours

The development of malignant tumours is defined by interactions between tumour cells and the stroma through cell membrane proteins and the release of cytokines. Ιt has been indicated that high concentrations of transforming growth factor (TGF-b1) inaggressive tumours of the breast, prostate etc. can promotecarcinogenesis. Aim: The aim of this study is to examine TGF-b1expression in malignant salivary gland tumours and correlateit with clinical parameters. Material and methods: 54 specimens of malignant salivary gland tumours obtained between 1996 and 2008(12 years) were the material of the study. 54 cases were evaluated 29 male and 25 female, 16-75 years of age. Results: TGF-b1 expression was weak and focal, locatedin neoplastic cells, as well as in the stroma. A positive correlation to tumour staging was also detected. Conclusions: TGF-b1 expression in malignant salivary gland tumours and its positive correlation with tumour staging provide a useful basis for the further investigation of its potential role as a prognostic index.