Prognostic value of cyclin- D1 and p16 in second primary oral squamus cell carcinoma

SUMMARY: Aim: To examine the prognostic value of cyclin-D1, p16 protein expression and other clinicopathological parameters in the evaluation of the clinical outcome and genetic profile of SPTs. Materials and methods: Immunohistochemical staining was performed in paraffin embedded specimens that were obtained from 25 patients with 80 second primary Oral Squamous Cell Carcinomas (OSCC). Results:Multivariate analysis revealed statistically significant positive relation of disease free survival (DFS) with cyclin-D1 overexpression (P=.015). Overall survival (OS) was not correlated significantly to none of the clinical and IHC parameters investigated. Synergistic action of cyclin-D1 with p16 failed to reach statistical significant relation with either DFS or OS in all fashions of expression.Different mode of expression was identified between the index and the first SPTs concerning bothcyclin-D1 and p16 (P<0.05). Conclusions: Patients with SPTs seem to outline a distinct entity in terms of clinicopathological behavior and genetic profile of the tumor cells. Moreover, the different prognostic value of cyclin-D1 overexpression and p16 loss of function in patients with SPTs makes our verification more potent.