ACTIVITY OF ETHANOLIC EXTRACT FROM Justicia gendarussa Burm. LEAVES ON DECREASING THE URIC ACID PLASMA

The effect of Justicia gendarussa leaves extract has been investigated using oxonate-induced hyperuricemic malealbino rats. In this experiment thirty five male albino rats were divided randomly into seven groups. There were threegroup doses variations of J. gendarussa extract that were 1.3 g/kg bw, 2.6 g/kg bw and 5.2 g/kg bw; two comparisongroups that were allopurinol 0.68 g/kg bw and herbal “X” 0.85 g/kg bw; and two control groups that were inducedcontrol potassium oxonate 0.25 mg/kg bw and normal control CMC 0,5 %. Intraperitoneal administration of potassiumoxonate 0.25 mg/kg bw was given one hour before administration of test drugs in eight day and plasma uric acid wasmeasured in rats after two hours. Plasma uric acid was measured by spectrophotometric on 520 nm with enzymaticmethod. The results showed that all extracts could reduced uric acid level of rats. The decreasing potency of uric acidlevel was equal to doses increase, so the best result that can reduce uric acid level was J. gandarussa extract at a dose5.2 g/ kg bw. This results indicated that J. gendarussa leaves extract may be effective for the prevention and thetreatment of hyperuricemia.