Chemical constituents and pharmacological studies of Lagerstroemia indica

Lagerstromia is commonly used as herbal tea in Phillipines. Due to its richness in polyphenolics that urges to investigate one of the cultivated species viz. L. indica. The aqueous methanol leaf extracts of Lagerstroemia indica L., prepared via two extraction methods (A & B), showed significant activities viz. anti- inflammatory, antipyretic, analgesic, antihyperglycemic, antioxidant and hepatoprotective moreover extract B showed higher activity as antihyperglycemic. The two natural products were identified for the first time from this plant, brevifolin (15) and decarboxyellagic acid (21). The known polyphenolics, p-methoxy gallic acid methyl ester (1);Gallic acid (2); 3-O-methylgallate (3); Tellimagrandin (4); Nilocitin (5); 1,3-di-Ogalloyl-4,6-hexahydroxydiphenoyl-β-4C1-glucopyranose (6); 2,3-hexahydroxydiphenic acid-α/β-glucoside (7); Isovitexin (8); Vitexin (9); Iso-orientin (10); Orientin (11); Astralagin (12); Rutin (13); Apigenin-7-O- 4C1-β-D-glucoside (14); Catechin (16); Epicatechin (17); Luteolin-7-O-4C1-β-D-glucoside (18); 3-methoxyellagic acid (19); Ellagic acid (20); Apigenin (22); Kaempferol (23); Luteolin (24) and Quercetin (25) were identified by different spectroscopic methods (UV, 1H-NMR and 13C-NMR). GC analysis of the derivatized hydrolyzed polysaccharide content revealed high amounts of mannose, rhamnose, glucose and galactouronic acids