Predictor value of some clinical-biological parameters for the onset of depressive disorder in elderly patients with unstable angina

. Objective: To evaluate the potential predictor value of some parameters for the onset of depression after an episode of unstableangina in elderly. Material and Methods: We included 103 elderly patients who suffered an acute unstable angina episode. Clinical, laband imagistic data was recorded in the first week after admittance. Six month after unstable angina episode, patients were evaluated for thepresence of depression. Results: Univariate analysis showed statistically significant association between depression and age, personal historyof myocardial infarction, arterial hypertension, type 2 diabetes, inadequate socio-economic status, absence of family, left ventricular ejectionfraction, LDL- and HDL-cholesterol values. Multivariate analysis showed that following clinical-biological parameters increase the probabilityof onset of depression six months after an unstable angina episode: history of myocardial infarction (OR, 12.8) and arterial hypertension(OR, 5.9). Adequate socio-economic status (OR, 0.145) and high levels of HDL-cholesterol (OR, 0.101) were considered protectors for onsetof depression. Conclusion: Several factors, like arterial hypertension or history of myocardial infarction, may increase the risk of depressionin elderly. High levels of HDL-cholesterol and adequate socio-economic status can prevent the onset of depression in patients that suffered anunstable angina episode.