The consequences of lead acetate intake on exposure and integrity biomarkers of reproductive system in female rats at sexual maturity (two generation study)

The aim of the study was the assessment of lead toxic impact on female reproductive systemintegrity and performances biomarkers. The objectives were: the evaluation of lead levels in ovary,Fallopian tubes and uterus (exposure biomarker) and the structural changes in ovary, Fallopian tubesand uterus (integrity biomarker) at sexual maturity consecutive exposure to lead acetate (50, 100, 150ppb Pb) in drinking water along two generation (F0, F1). The study pointed out significant increase of leadlevel in ovaries, Fallopian tubes and uterus comparative to the control group and direct corelation, withdifferent degrees of significance, with the exposure level; severe congestive and degenerative changes inovary (destruction of parenchymatosa zone, vacuolar epithelial cells, passive vascular congestion,edematous follicle without oocytes, follicle with oocytes) and uterus (necrosis of uterine glands,destruction of uterine lining cells, total detachments of the superficial layers of the epithelia, hypertrophyof the epithelia).