Hydrolysable Tannins and Related Compound having Cytotoxic Activity of Geranium Wilfordii Maxim

In order to exhibit moderate cytotoxic activity toward the human tumor cell lines including A-549, SK-OV-3, HT-1080, K562 and S180, the cytotoxicity-directed fractionation of Me OH extract of Geranium wilfordii Maxim led to the isolation of three hydrolyzed tannins and a related compound, Gallic acid (I), 1, 2, 3, 4, 6-penta-O-galloyl-&beta-D-glucopyranose (ll), chebulagic acid (Ⅲ) and chebulinic acid (IV), as active principles. They were shown to exhibit moderate cytotoxicity against cultured human tumor cell lines including A549, SK-OV-3, HT-1080, K562 and S180 in vitro.