SYNTHESIS, CHARACTERIZATION, BIOLOGICAL EVALUATION AND ANTI–CORROSION ACTIVITY OF PIPERIDIN-4-ONE DERIVATIVES

4-Thiazolidinone has been prepared by the reaction of various Schiff bases (2,4) with thioglycolic acid in presence of anhydrous zinc chloride and solvent N,N-Dimethyl formamide to afforded novel componds of 4-thiazolidinone (3,5), The intermediate Schiff base were synthesized by the condensation of 2,6-bis (m-chloro phenyl) 3,5-dimethyl-4-piperidone-4 (1) with 4,4'-diaminodiphenylsulphone (2) and 4-methylbenzene -1,3-diamine (4) The structure of all the synthesized compounds were elucidated by spectral (IR,1H-NMR,13C-NMR and Mass) and elemental (C,H,N) analysis. All the synthesized compounds have been screened for their antibacterial properties against various bacterial strains in order to obtain chemotherapeutic properties and these compounds were tested to determine their ability to inhibit corrosion of mild steel in 1 mol.l-1H2SO4 and measured by polarization measurements. The studies revealed that nitrogen, the piperidine moiety, the phenyl ring, 4-thiazolidinone assist largely in corrosion control.